Sibo Meets the Earth Man by Ginny Stone
By Ginny Stone
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Extra resources for Sibo Meets the Earth Man
Development and application of fluorescence polarization assays in drug discovery. Comb Chem High Throughput Screen, 6(3): 183-194. S. (2004). The role of natural product chemistry in drug discovery. , 67(12): 2141-2153. S. (2008). Natural products to drugs: natural product-derived compounds in clinical trials. , 25(3): 475-516. S. J. (2008). Mother Nature's gifts to diseases of man: the impact of natural products on anti-infective, anticholestemics and anticancer drug discovery. , 65(1): 3-44.
Strategies for discovering drugs from previously unexplored natural products. Drug D~scou Today, 5(7): 294-300. L. (2007). Natural products as a screening resource. , 11(5): 480-484. R. H. (2008). Prevention and treatment of type 2 diabetes: Current role of lifestyle, natural product, and pharmacological interventions. , 118(2): 181-191. Home, P. (2003). The challenge of poorly controlled diabetes mellitus. , 29(2 Pt 1): 101-109. C. and Receveur, T. (2008). Small animal PET imaging. , 49(1): 54-65.
Further, this may be poorly correlated to clinical outcomes in man. The pharmacokinetics and pharmacodynamics (PK-PD) of the compound in humans, which becomes clear only after the first dose in healthy volunteers, will help in determining the dose and route of administration. Research in normal human volunteers and patients enables a clearer understanding of the biology and pathophysiology, and can therefore trigger innovations in in vitro and animal experiments that better mimic the clinical condition.