Ciba Foundation Symposium 153 - Steroids and Neuronal by CIBA Foundation Symposium

By CIBA Foundation Symposium

Classical reports of steroid hormones are taken with their rules of protein synthesis through the modulation of genomic transcription. yet some of the activities of those hormones ensue too swiftly to be defined during this demeanour, fairly their results at the crucial anxious approach. this article offers with fresh discoveries exhibiting that steroids can modulate the task of a few neurotransmitters. It explores the function of GABA as an incredible regulator of neuronal task within the principal anxious approach and its inhibitory motion as mediated through the GABA receptor and potentiated through steroids. moreover, the binding of steroids to mobilephone membranes, the parts concerned and the end result of such interactions are defined. additionally discusses attainable makes use of of steroids as anesthetics and anticonvulsants.

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K. (HD 70,006). We acknowledge the valuable contributions to this work made by the following colleagues in addition to those cited: R. Bleier, Y. Cheng, A. E. Colas, J. A. Czaja, D. Goldfoot, R. W . Goy, S. Herf, C. J. Mapletoft, R. K. Meyer, F. Nowak, J. Robinson, D. Smith and B. Sridharan. References Bertics PJ, Karavolas HJ 1984 Partial characterization of the microsomal and solubilized hypothalamic progesterone 5a-reductase. J Steroid Biochem 21 :305-3 14 Neuroendocrine metabolism of progesterone 43 Bertics PJ, Karavolas HJ 1985 Pituitary progesterone Sa-reductase: solubilization and partial characterization.

Some of them are quite high. Karavolas: Yes, some of the K, values for these enzymes for Czl substrates in the oxidative direction are in the pM range, as compared to the K , values in the nM range for substrates in the reductive direction. This may indicate a preferred direction. However, both sets of values are within the range of reported plasma concentrations of these steroids. If these kinetic parameters are similar for the enzymes from males, I believe the levels of progesterone and 3a,5aT H P secreted by the adrenals (Holzbauer et a1 1985) are within these ranges, especially for the reductive direction.

The formation of Sa-DHP Neuroendocrine metabolism of progesterone 35 PROGESTERONE AND / OR ACTIVE METABOLITES (eg. e. 5a-DHP; 3a,Sa-THP, ETC) \ '7 CONVERSION TO I V I t' VIA HORMONE RECEPTORS, NUCLEAR INTERACTIONS, NON - GENOMIC EFFECTS, DIRECT EFFECTS, ETC. g; synthesis / release of LH IFSH, lordosis behavior, anesthesia, modulation of GABA receptors, etc. 1. OTHER HORMONES, ETC. FOR NECESSARY INTERACTIONS OR PERMISSIVE EFFECTS. 2 TERMINATION OF EFFECT:* DEGRADATION (INACTIVE METABOLITES. ETC.

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