The Behavioral Neurology of White Matter by Christopher Filley

By Christopher Filley

Behavioral neurology is based on lesions of cortical grey subject, yet lately the contributions of cerebral white subject to cognitive and emotional disorder have additionally attracted realization. The Behavioral Neurology of White Matter surveys this large and interesting box from a medical viewpoint. motivated by means of fresh advancements in neuroimaging, white subject has been conscientiously studied, and its function within the operations of cognition and emotion clarified via correlations with scientific observations. The relevance of ordinary and irregular white topic to behavioral neurology is obvious in each context the place this query has been tested: in improvement, getting older, and in a bunch of illnesses, intoxications, and accidents. because the first variation of this publication in 2001, regular advances were made in knowing the neurobiology of white topic and its scientific value; this variation presents a entire replace in this speedily increasing box. each bankruptcy has been widely rewritten, together with a entire revision of the account of the neuropsychiatry of white topic, a very hard region. The syndrome of white topic dementia is mentioned intimately, and its refinement with new info is taken into account in addition to the thought of light cognitive disorder as a precursor syndrome in lots of medical settings. furthermore, new chapters were additional, one at the rising zone of white topic adjustments linked to neurodegenerative problems such Alzheimer's ailment, and one other on neurologic facets of white topic together with fascinating new details on white subject plasticity. A unifying subject matter is the concept that of connectivity, because it is obvious the white topic varieties a vital part of the common allotted neural networks wherein cognition and emotion are equipped. as well as the microconnectivity inside of grey subject that subserves details processing, the macroconnectivity of white topic permits info move - either are serious for the features of the human brain.

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Dev Neurosci 2002; 24: 255–261. Lee PR, Fields RD. Regulation of myelin genes implicated in psychiatric disorders by functional activity in axons. Front Neuroanat 2009; 3: 4. Luria AR. Higher cortical functions in man. New York: Consultants Bureau, 1980. Mandell AM, Albert ML. History of subcortical dementia. In: Cummings JL, ed. Subcortical dementia. New York: Oxford University Press, 1990: 17–30. McHenry LC. Garrison’s history of neurology. Springfield, IL: Charles C Thomas, 1969. 1. The Neurologic Background 21 McHugh PR, Folstein MF.

1990), and toluene leukoencephalopathy provided one of the best examples of dementia from white matter disease (Chapter 9). Since its introduction, MRI has continued to reveal an impressive variety of cerebral white matter abnormalities in many populations. , 1987), which has raised many questions about the origin and impact of vascular white matter disease (Chapter 11). The study of previously known white matter diseases also advanced rapidly with the arrival of MRI, as the example of MS readily demonstrates.

In the brain, where the operations of many distributed neural networks depend critically on normal communication between widely dispersed regions, integrity of the white matter tracts is a necessary condition for normal function. Although the idea of neural networks has assumed a prominent position in thinking about brain–behavior relationships, the cortical and subcortical gray matter nodes of these networks are often emphasized without mention of the white matter systems by which they are connected.

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