The role of interleukin-2 in the treatment of cancer by John Wagstaff (auth.), John Wagstaff MD, MB, ChB, MRCP

By John Wagstaff (auth.), John Wagstaff MD, MB, ChB, MRCP (eds.)

Recombinant human interleukin-2 grew to become to be had for medical use within the mid Eighties. fresh years have obvious a big volume of medical learn with this cytokine and interleukin-2 has now been registered to be used in a couple of ecu international locations for the therapy of metastatic renal phone carcinoma. This e-book is designed to supply the scientific oncologist wishing to exploit interleukin-2 with a uncomplicated history in regards to the biology of the agent, a dialogue bearing on sensible features, of its medical use together with administration of toxicity and an outline of the medical effects including an outline of ways this internesting cytokine could be built within the future.

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Extra info for The role of interleukin-2 in the treatment of cancer patients

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A different regimen was therefore tested. The first report of continuous infusion of IL2 together with LAK cells was made by West et al. in 1987 [28]. e. 18 x 106 IU/m 2 /day. The duration is identical to that of Rosenberg's regimen with only the dose and the mode of administration being different. LAK cell administration is also possible together with a combined therapy of IL2 and Interferon alpha [29]. The administration of IL2 and LAK cells can also be used in paediatric oncology [30]. The results reported by different authors using systemic IL2 and LAK cells are summarised in Table 1.

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84. Syman M, Bosly A, Gisselbrecht C, et al. Immune reconstitution after bone-marrow transplantation. Cancer Treat Rev 1989; 16(Suppl A): 15-9. 85. Bosly AE, Staquet P J, Doyen CM, et al. Recombinant human interleukin-2 restores in vitro Tcell colony formation by peripheral blood mononuclear cells after autologous bone marrow transplantation. Exp Hematol 1987; 15: 1048-54. 86. Heslop HE, Price GM, Prentice HG, et al. In vitro analysis of the interactions of recombinant IL-2 with regenerating lymphoid and myeloid cells after allogeneic marrow transplantation.

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