The Role of Wnt Signalling in the Development of Somites and by Corina Schmidt, Imelda McGonnell, Steve Allen, Ketan Patel

By Corina Schmidt, Imelda McGonnell, Steve Allen, Ketan Patel

The Wnt relations of secreted signalling molecules controls a variety of developmental techniques in all metazoans. during this research, the authors have focused on the function that participants of this kinfolk play in the course of the improvement of the somites and the neural crest. ultimately they've got remoted a singular portion of the Wnt signalling pathway referred to as bare Cuticle and investigated the function that this protein may well play in either the formerly pointed out strategies.

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Extra info for The Role of Wnt Signalling in the Development of Somites and Neural Crest

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3A). Some Pax3 expression was detected directly adjacent to the dorsal neural tube coinciding with a small region that remained in an epithelial state. Examination of a marker of the ventral compartment, Pax1, following ectoderm removal showed robust expression of the gene at the site of operation. Expression levels of Pax1 on the operated side were similar to those on the control side (Fig. 3B). Paraxis, a marker for the epithelialisation of the paraxial mesoderm (Burgess et al. 1995; Barnes et al.

At later stages (HH22) there were fewer neural crest cells in the adjacent somites, indicated by Sox10 expression (data not shown). Wnt1 and Wnt3a expression were not affected (data not shown), indicating the specificity of the siRNA Fig. 13 A–K (continued) D, E Wnt1 induces translocation of β-catenin to the nucleus in many dorsal neural tube cells. Arrowheads indicate numerous labelled nuclei. F Wnt6-implanted and G Wnt1-implanted embryos do not show differing levels of TUNEL labelling. H The control embryo demonstrates RhoA is expressed ventrally (arrow).

E Whole mount in situ hybridisation for cNkd1 of a 3-day-old chick embryo after removal of the notochord at the level of the segmental plate and following re-incubation for 20 h. At the operation level there is a stronger cNkd1 expression in the newly formed somites (red arrow) and in the neural tube (black arrow). F Transverse section of the embryo shown in E reveals a stronger expression of cNkd1 in the somite (red arrows) and in the dorsal neural tube (black arrow) at the operation level The Regulation of cNkd1 Expression 35 Fig.

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