Transdermal Drug Delivery, Second Edition, Revised and by Richard H. Guy, Jonathan Hadgraft

By Richard H. Guy, Jonathan Hadgraft

Thoroughly revised, the second one variation of Transdermal Drug supply offers discussions of the major concerns pertinent to transdermal drug supply. masking the intensity and breadth of the sphere, from actual chemistry and evaluate of drug permeability to to be had enhancement applied sciences, to regulatory approval, the booklet examines issues essential to the severe overview of a drug candidate's strength for supply around the pores and skin. It describes tips on how to be sure the transdermal permeability of gear, how rationally to choose applicants for transdermal supply, tips to select chemical and/or actual ways to improve pores and skin shipping, and the way to resolve regulatory concerns.

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Additional info for Transdermal Drug Delivery, Second Edition, Revised and Expanded (Drugs and the Pharmaceutical Sciences)

Example text

This barrier may affect in vitro penetration of the more lipophilic chemicals but probably does not contribute during in vivo absorption in which the dermis layer is normally wellperfused by capillary blood flow. All of the equations examined in this work consist of parameters developed from regressions of experimental measurements. Some permeability coefficient equations are appropriately termed semitheoretical because the chosen functional form of their parameters conforms to a theoretical model.

In vitro assessments of transdermal devices containing nitroglycerin. International Journal of Pharmaceutics 1991; 73(2):125–130. J Hadgraft, D Beutner, HM Wolff. In vivo–in vitro comparisons in the transdermal delivery of nitroglycerin. International Journal of Pharmaceutics 1993; 89(1):R1–R4. RH Guy, J Hadgraft. Rate control in transdermal drug delivery? International Journal of Pharmaceutics 1992; 82:R1–R6. J Hadgraft. Pharmaceutical aspects of transdermal nitroglycerin. International Journal of Pharmaceutics 1996; 135(1–2):1–11.

Predicting skin permeability. Pharmaceutical Research 1992; 9(5):663–669. SC Valvani, SH Yalkowsky, TJ Roseman. Solubility and partitioning. 4. Aqueous solubility and octanol–water partition-coefficients of liquid nonelectrolytes. Journal of Pharmaceutical Sciences 1981; 70(5):502–507. T Yano, A Nakagawa, M Tsuji, K Noda. Skin permeability of various nonsteroidal anti-inflammatory drugs in man. Life Sciences 1986; 39:1043– 1050. T Degim, J Hadgraft, WJ Pugh. Modelling the transdermal delivery of nonsteroidal anti-inflammatory agents.

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