Vesicle Trafficking in Cancer by Alexander Sorkin, Manojkumar A. Puthenveedu (auth.), Yosef

By Alexander Sorkin, Manojkumar A. Puthenveedu (auth.), Yosef Yarden, Gabi Tarcic (eds.)

Endocytosis and vesicular trafficking confirm the panorama of the cell’s external, particularly the density of floor molecules, similar to receptors for development components and cytokines, adhesion molecules like integrins and cadherins, and a plethora of nutrient companies. as a result, endocytosis is all in favour of sign transduction, mobilephone adhesion and migration, in addition to metabolism. to take advantage of those primary techniques, malignancies subtly and multiply control the endocytosis and the following trafficking of protein cargoes. this can be completed via concurrently changing the cytoskeleton, vesicle budding, shipment sorting and intracellular degradation. by means of highlighting the underlying molecular procedures and focusing on particular examples, this publication experiences the new emergence of derailed endocytosis and vesicular trafficking as a landmark of melanoma. In-depth figuring out of this universal characteristic of tumors may prepared the ground to drug-induced concepts, in a position to rectify intracellular trafficking in cancer.

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Erdmann KS, Mao Y, McCrea HJ, Zoncu R, Lee S, Paradise S, Modregger J, Biemesderfer D, Toomre D, De Camilli P (2007) A role of the lowe syndrome protein OCRL in early steps of the endocytic pathway. Dev Cell 13(3):377–390 70. Sorkin A, von Zastrow M (2009) Endocytosis and signalling: intertwining molecular networks. Nat Rev Mol Cell Biol 10(9):609–622 71. Rao Y, Rückert C, Saenger W, Haucke V (2012) The early steps of endocytosis: from cargo selection to membrane deformation. Eur J Cell Biol 91(4):226–233 72.

A potential explanation for this is that different signals bind different domains on the same adapter [47]. As described above, the Yxxφ and diLeu motifs bind distinct regions on adapters, and data suggest that the binding of these signals might be independent of each other [32]. Elucidation of the exact binding domains for various other signals and cargo will provide a better understanding of how multiple cargos can be endocytosed without too much interference. An additional question that is gaining increasing interest is whether there are biochemically distinct subsets of CCPs, as defined by distinct cargo molecules.

Huang F, Kirkpatrick D, Jiang X, Gygi S, Sorkin A (2006) Differential regulation of EGF receptor internalization and degradation by multiubiquitination within the kinase domain. Mol Cell 21(6):737–748 161. Umebayashi K, Stenmark H, Yoshimori T (2008) Ubc4/5 and C-cbl continue to ubiquitinate EGF receptor after internalization to facilitate polyubiquitination and degradation. Mol Biol Cell 19(8):3454–3462 162. Huang F, Goh LK, Sorkin A (2007) EGF receptor ubiquitination is not necessary for its internalization.

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